Ares of Focus - Our Science | Translucence Biosystems

Products

Adapts the ZEISS Lightsheet Z.1 and Lightsheet 7 microscopes, designed for imaging small live organisms, to image large intact tissues with unprecedented speed and resolution

Stitchy™

Accelerate and streamline your image processing workflow with Stitchy: The ultimate stitching tool built by scientists who analyze images every day

Translucence Universal Tissue Clearing Kit

Clear and stain an extensive range of tissues, including mouse brain, lung, liver, spinal cord, and more using your preferred antibodies

Translucence Neuronal Activity Tissue Clearing Kit

Use our validated antibodies to measure cFos and Npas4, providing rich, detailed insights into systems-level activity

Services

Custom services

3D Tissue Clearing

Custom tissue clearing solutions

3D Tissue Imaging

High-resolution, three-dimensional imaging of large intact samples

Light Sheet Image Stitching

Custom stitching of terabyte-sized datasets using Stitchy

AI-Powered 3D Quantification

Rapid generation of custom assays using the Translucence Teravoxel Toolkit (3TK)

Full-pipeline services

Alzheimer’s Disease

Brain-wide assay to measure β-amyloid plaque deposition

Parkinson’s Disease

Brain-wide assay to measure ɑ-synuclein & Tyrosine Hydroxylase

Neuroinflammatory Diseases

Brain-wide measurements of neuroinflammatory responses within the CNS via the microglial marker Iba1

Neuronal Activity

Brain-wide cellular resolution measurement of recent neuronal activity

Therapeutic Antibody Detection

Brain-wide assay for measuring the target engagement, efficacy, and distribution of novel antibody therapeutics

Liver Bile Ducts and Tubular Structures

3D Bile-duct visualization and quantification

Whole-Organ Vasculature Staining

Visualization of vasculature

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Science

Our Pipeline

3D Tissue Clearing

Three-dimensional insights into the structure and function of intact biological sample

3D Tissue Imaging

High-resolution, three-dimensional imaging of large intact samples with unprecedented speed and resolution

3D Light Sheet Image Stitching

Autonomous stitching of terabyte-scale 3D imaging datasets 2.5-5.5 times faster than leading commercial software solutions

3D AI-Powered Quantification

Leveraging artificial intelligence for quantitative analysis of 3D histological data

Research Areas

Alzheimer's Disease

Whole-brain quantification of β-Amyloid plaque distribution for insights into Alzheimer's Disease Pathology.

Liver Bile Ducts and Tubular Structures

3D Bile-Duct Visualization and Quantification

Neuroinflammatory Diseases

Whole sample neuroinflammation measurements via the staining, imaging, and quantification of iba+ microglia

Neuronal Activity

Whole-brain measurement of recent changes in neuronal activity

Parkinson’s Disease

Whole-brain measurement of ɑ-synuclein & Tyrosine Hydroxylase for insights into Parkinson’s Disease Pathology.

Therapeutic Antibody Detection

Whole-brain quantification of human based antibody therapeutics

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About Translucence Biosystems

About

We provide researchers and clinicians with fast, reliable
and complete 3D analysis of their biological samples

Our Team

Learn more about our founders and how Translucence Biosystems is enabling a dimensional shift from 2D to 3D histology

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Areas of Research

Alzheimer's Disease

Parkinson’s Disease

Neuroinflammatory Diseases

Neuronal Activity

Therapeutic Antibody Detection

Liver Bile Ducts and Tubular Structures

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