Research

When Nathan Hyman joined Translucence Biosystems as an undergraduate intern at the University of Michigan, he had no prior laboratory experience. Yet within months, Hyman was generating publication-quality 3D anatomical data that would later be featured at the 2024 Society for Neuroscience meeting. The following article describes how Hyman leveraged iDISCO-based tissue clearing methods, light sheet imaging, and Al-powered whole-brain object segmentation, to generate regionalized data across hundreds of brain regions.

Co-Founder, Sunil Gandhi Ph.D., gave a talk entitled "Brain-wide single-cell resolution anatomics" at the recent 20th Annual Advanced Imaging Methods Workshop hosted by the CRL Molecular Imaging Center at the University of California, Berkeley. The talk focused on new statistical methods for handling the hierarchical anatomical definitions of the Allen Brain Atlas.

The Translucence team, including Nate Guanzon, Chase Redd, and CEO Damian Wheeler presented our BRAIN Initiative-funded work on whole-brain quantification neuronal activity with Npas4 and cFos at SfN 2022.

Translucence presented their whole-brain regional assays for β-Amyloid plaques and microglia and their collaborative work with Lundbeck measuring antibody therapeutics crossing the Blood-Brain Barrier and homing in on their target.

Recent advances in optical clearing and light sheet imaging have opened an exciting new avenue for brain-wide, cellular resolution immunostaining at the forefront of a dimensional shift from 2D to 3D histology. With access to the intricate anatomy of the whole intact brain, we are developing unbiased and complete pictures of brain pathology for pre-clinical studies.

Translucence Biosystems is honored to present at the Society for Neuroscience's 50th Annual Meeting. Our presentation is entitled, "Brain-wide cellular resolution snapshots of neuronal activity with Npas4 and cFos". View our presentation materials here.